Scientific Publications
14Jun, 2021
Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer’s Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression
Martin Tolar, John Hey, Aidan Power, Susan Abushakra
4Dec, 2020
APOE ε4/ε4 homozygotes with early Alzheimer’s disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline
Susan Abushakra, Anton P. Porsteinsson, Marwan Sabbagh, Luc Bracoud, Joel Schaerer, Aidan Power, [...]
17Aug, 2020
Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid targeting drugs for Alzheimer’s disease with potential for near term approval
Martin Tolar, Susan Abushakra, John A. Hey, Anton Porsteinsson and Marwan Sabbagh
3Jan, 2020
The path forward in Alzheimer’s disease therapeutics: Reevaluating the amyloid cascade hypothesis
Martin Tolar, Susan Abushakra, Marwan Sabbagh
2Dec, 2019
APOE4/4 Subjects with Early Alzheimer’s Disease Show Accelerated Loss of Cortical Thickness and Cognitive Decline Compared to APOE3/3 Subjects
Background & Objectives The apolipoprotein ε4 allele (APOE4) is a major genetic risk [...]
24Oct, 2018
APOE4/4 Early to Mild AD Subjects Show High Rates of Hippocampal Atrophy and Cognitive Decline in ADNI-1 and Tramiprosate Datasets
Susan Abushakra MD, Luc Bracoud MS, Joël Schaerer, Aidan Power MD, John Hey [...]