Scientific Publications
3Jan, 2020
The path forward in Alzheimer’s disease therapeutics: Reevaluating the amyloid cascade hypothesis
Martin Tolar, Susan Abushakra, Marwan Sabbagh
2Dec, 2019
APOE4/4 Subjects with Early Alzheimer’s Disease Show Accelerated Loss of Cortical Thickness and Cognitive Decline Compared to APOE3/3 Subjects
Background & Objectives The apolipoprotein ε4 allele (APOE4) is a major genetic risk [...]
24Oct, 2018
APOE4/4 Early to Mild AD Subjects Show High Rates of Hippocampal Atrophy and Cognitive Decline in ADNI-1 and Tramiprosate Datasets
Susan Abushakra MD, Luc Bracoud MS, Joël Schaerer, Aidan Power MD, John Hey [...]
24Oct, 2018
Clinical Effects of Oral Tramiprosate in APOE4/4 Homozygotes with Mild Alzheimer’s Disease (AD): Responder Analyses of Cognitive and Functional Outcomes
Susan Abushakra MD*, Bruno Vellas MD, Serge Gauthier MD, Anton Porsteinsson MD, Carl Sadowsky [...]
3Aug, 2018
Discovery and Identification of an Endogenous Metabolite of Tramiprosate and its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation In Human Brain
John A. Hey, Petr Kocis, Jakub Hort, Susan Abushakra, Aidan Power, Martin Vyhnálek, Jeremy Y. Yu & Martin Tolar
25Jul, 2018
Clinical Benefits of Oral Tramiprosate in APOE4/4 Homozygotes with Mild Alzheimer’s Disease (AD): Responder Analyses from the Phase 3 North American Trial
S. Abushakra, A. Porsteinsson, C. Sadowsky, S. Gauthier, B. Vellas, A. Power, L. [...]