ALZ-801 promotes amyloid clearance from brain

Amyloid-oligomers-drive-neurotoxicity-and-tau-pathology_Alzheon

Alzheon publication: Tolar (2024) Int J Mol Sci

Amyloid oligomers drive neurotoxicity & tau pathology

Injured neurons release misfolded tau protein that aggregates into tangles

Amyloid clearance from brain to plasma via astrocyte end-feet on capillaries & by glial uptake

Tarasof-Conway (2015) Nat Rev Neurol; Bagheri (2013) PLOS One

Valiltramiprosate blocks amyloid aggregation in brain, promotes efflux of monomers to plasma & activation of astrocytes

ALZ-801 Blocks Amyloid Aggregation

Tarasof-Conway (2015) Nat Rev Neurol & Bagheri (2013) PLOS One

Assay to measure neurotoxic amyloid oligomers in brain

  • Alzheon collaborates with Czech Institute of Organic Chemistry & Biochemistry to develop commercial assay to measure neurotoxic amyloid oligomers in brain
  • Diagnostic & theragnostic assay enables early intervention with valiltramiprosate
  • Measurement of brain oligomer burden enables treatment & prevention:
    1. Monitoring of progress & assessment of treatment impact in patients
    2. Intervention years before emergence of clinical symptoms in cognitively normal individuals with increased risk for Alzheimer’s

Mass spectrometry detects soluble amyloid oligomers

Kocis (2017) CNS Drugs