Central Role of Amyloid Oligomers in Alzheimer’s

A large body of scientific evidence suggests that neurotoxic soluble amyloid oligomers trigger neuronal damage and cell death leading to Alzheimer’s disease (AD).

Targeting amyloid oligomers critical to slow progression

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Amyloid Oligomers to Slow Alzheimers

Alzheon publications: Tolar (2021) Int J Mol Sci; Tolar (2020) Alzheimers Res Ther; Tolar (2019) Alzheimers Dement

ALZ-801 (valiltramiprosate) is designed to inhibit amyloid oligomer formation

Our lead product candidate, ALZ-801, is designed to inhibit amyloid oligomer formation, a key driver of Alzheimer’s disease. We believe ALZ-801 has the potential to be differentiated from other emerging therapies targeting Alzheimer’s disease pathology due to its novel mechanism of action, oral mode of administration and potential efficacy in a genetically-targeted population. If our development program is successful and ALZ-801 is approved, it has the potential to be among the first drugs to intervene in an underlying mechanism of Alzheimer’s disease.


Neurotoxic soluble amyloid oligomers present early in AD

  1. Amyloid oligomers damage neurons and trigger disease
  2. Oligomer levels in brain increase & drive clinical progression
  3. APOE4/4 homozygotes form more oligomers leading to an earlier disease onset
  4. Value of targeting oligomers in APOE4 patients supported by clinical evidence from aducanumab & lecanemab programs
Alzheon publications: Tolar (2021) Int J Mol Sci; Tolar (2020) Alzheimers Res Ther; Hey (2018) CNS Drugs; Kocis (2017) CNS Drugs

Enveloping mechanism of action of ALZ-801

Multiple molecules bind to amyloid & prevent toxic oligomer formation

  • Several molecules surround & interact with beta amyloid monomers
  • Stabilize shape of amyloid monomers & block formation of neurotoxic oligomers
  • Interact with key amino acids on beta amyloid monomer

Alzheon publications: Hey (2018) CNS Drugs; Kocis (2017) CNS Drugs

ALZ-801 protects native state of beta amyloid protein

Multiple molecules of ALZ-801/tramiprosate form an enveloping cloud around Aβ42 amyloid monomer that maintains its native shape & prevents aggregation into toxic oligomers

Amyloid conformation enforced by ALZ-801

Influenced by surrounding cloud of excess ALZ-801 molecules, Aβ42 amyloid monomer adopts shape that blocks formation of oligomers