ALZ-801 promotes amyloid clearance from brain

Amyloid-oligomers-drive-neurotoxicity-and-tau-pathology_Alzheon

Alzheon publication: Tolar (2024) Int J Mol Sci

Amyloid oligomers drive neurotoxicity & tau pathology

Injured neurons release misfolded tau protein that aggregates into tangles

Amyloid clearance from brain to plasma via astrocyte end-feet on capillaries & by glial uptake

Tarasof-Conway (2015) Nat Rev Neurol; Bagheri (2013) PLOS One

Valiltramiprosate blocks amyloid aggregation in brain, promotes efflux of monomers to plasma & activation of astrocytes

ALZ-801 Blocks Amyloid Aggregation

Tarasof-Conway (2015) Nat Rev Neurol & Bagheri (2013) PLOS One