Our Pipeline

Our lead oral product, ALZ-801, is ready for Phase 3 in Alzheimer’s

Focused on mild Alzheimer’s patients
Targeted patient selection based on APOE4 genotype
Granted Fast Track Designation by FDA for development in Alzheimer’s disease

ALZ-801 is an improved prodrug of tramiprosate which showed

Promising clinical signals in a subset of Alzheimer’s patients
Well tolerated, long-term safety evaluated in 2,000 patients at effective clinical dose

Our next clinical candidate is ALZ-507

Rapid path to clinic with IND planned for early 2020
In development for additional amyloid-related disorders

Our next generation candidate is ALZ-1903

New chemical entity
More potent inhibitor of amyloid misfolding

Discovery Platform

Rich and diverse compound libraries enabled by the novel mechanism of action
Designed to inhibit the misfolding of amyloids and other proteins associated with neurodegenerative diseases

Consistent efficacy across biomarker & clinical studies

Alzheon Pipeline - Efficacy Across Biomarker & Clinical Studies

ALZ-801 pill inhibits the formation of amyloid oligomers

Alzheon_ALZ-801-amyloid-oligomers-alzheimers

ALZ-801 differentiation from amyloid antibodies

ALZ-801 differentiation from amyloid antibodies

Source: Binding profiles of BAN2401, Gantenerumab, Aducanumab, Crenezumab and Solanezumab are based on peer reviewed publications and information disclosed by competitors